Anticancer Activity of Heterocyclic Ligand-platinum Metal Complexes

A wide range of research activities have been carried out so far on benzimidazole and pyridine derivatives to evaluate their Antiviral, Anticancer, Anticonvulsant, Anthelmintic Activity and many promising results are obtained with respect to the anticancer activity. Out of the various ligands used, the alkylating agents are found to be highly active with respect to cancer chemotherapy. Nitrogen mustards, ethylenemines, alkylsulfonates, nitrosourea, and triazines are all members of the alkylating agents. The presence of active nitrogen atom in a particular structure enhances the binding efficacy of number of metals and hence forms metal complexes. The overall aim of the review is to study cytotoxicity of various platinate and other metal complexes which are effectively formed by platinum and other metals respectively by obtaining the lone pair of electrons from nitrogen. Also in support of the anticancer activity, the derivatives obtained by metal complexation with number of nitrogen containing heterocyclic ligands have been shown. Keyword: Benzimidazole, Pyridine, Platinum Complexes, Anticancer Activity, Cytotoxic Activity